[Dr. Beni 88 365] Men Happy drag of (Happy drug), testosterone
Testosterone is not only the hypothalamus of the brain associated with sexual function, even in the periphery plays a key role in the regulation of male erectile function.
Testosterone, which regulates the production of nitrogen oxide to an important role in the initiation and maintenance of erection (nitric oxide). Moreover, to improve blood flow in the corpora cavernosa, thereby maintaining the proper function of the oral erectile dysfunction therapeutic agent at a PDE5 blockers (such as Viagra). If you lack, therefore, it is a sexual dysfunction.
Testosterone (testosterone) is a male hormone will be naturally reduced by each year before and after the late 30s. When it comes to 40 to 50 generations testicular functions are weakened, testosterone is further reduced. As a result, the acquired hypogonadism that more of the symptoms occur (LOH: Late Onset Hypogonadism) or male hormone deficiency syndrome (testosterone deficiency syndrome) that.
Once in the menopause and symmetrical meaning of women acquired hypogonadism, was name to male menopause (andropause, male menopause). However, men as women, fertility is not suspended in the wake of menopause. Onset of symptoms also by individuals are many, there is a case that testosterone decreases in men of 20 to 30 generations, it is no longer rarely used.
Or function of the male testes is weakening, I feel the fatigue accompanied by a sense of helplessness due to a decrease in muscle mass and strength when testosterone comes to decrease in other causes. The decrease in libido, decrease in erection force, reduction of ejaculate volume, sexual dysfunction, such as reduction of pleasure at the time of ejaculation, are displayed first
Acquired hypogonadism, since it is also vague to distinguish the normal aging processes, recently, it has been defined in a syndrome characterized by the following seven conditions.
1) decreased libido, erectile dysfunction (frequency quality), especially at night of erectile dysfunction
2) intellectual activity, cognitive function, reduction of space disorientation, fatigue, depression, mood with irritation change
3) sleep disorders
4) it is associated with a decrease in muscle mass and strength, reduction in body fat
5) Increase in visceral fat
6) reduction of body hair and skin changes
7) decrease in bone density
Diagnosis of acquired hypogonadism (LOH), after sufficient troops listening and appropriate interview, if the symptoms, such as described above appeared, blood was collected total testosterone (total testosterone), glass testosterone ( We want to test a number of free testosterone).
When scanning, usually often inspecting only the total testosterone, they may occasionally numerical test is properly displayed, it is possible committing errors. Therefore, it is necessary to glass testosterone Lulu parallel test can be more accurately diagnosed.
Result of the test, the total testosterone or less than 240ng / dL, when the glass testosterone is below 50pg / mL, is required testosterone replacement therapy has been established in the acquired hypogonadism.
Result of the test, or appear symptoms associated with testosterone deficiency when the total testosterone 241~346ng / dL or glass testosterone is 51~72pg / mL, when it is generated by the following age 40s, the treatment of the subject and it is.
However, even if the symptoms, total testosterone or at 346ng / dL or more, if the glass testosterone is 72pg / mL or more, not require replacement therapy for testosterone. If ambiguous re-examination and SHBG between the lower limit value testosterone value is normal, it is necessary to be a secondary inspection, including luteinizing hormone and prolactin.
In LOH patients with erectile dysfunction, which can not react with hormone replacement therapy alone. In this case it is possible to see the effect when the additional use of a PDE5 blockers. Patients of erectile dysfunction which do not react similarly to the PDE5 blocker, may involve their testosterone hyperlipidemia, in this case, replacement therapy is useful. Also, when accompanied by anxiety for performing sexual activity, trazodone used is an anti-anxiety agents are also recommended.
Oral testosterone is not soluble in water, are restrictions on the absorption many, prescribe a lot of non-oral drug, such as for a main injection and transdermal is a disadvantage that is rapidly metabolized in the liver.
Although many people might have hesitated for a sense of anxiety for cancer for hormone therapy, testosterone, can be safely administered after some tests. Prostate cancer and breast cancer patients, severe polycythemia, sleep apnea that is not treated, severe heart failure, it is not administered if there is dysuria in the lower urinary tract closures and benign prostatic hyperplasia. However, when it is dysuria treatment can be administered.
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